Due to high viscosity, thin reservoir and the serious situation of steam channeling and overriding, it is urgent for Henan specific oil field to change its development pattern. Based on physical experiments and numerical simulation, the suitability of nitrogen-foam flooding is studied. As indicated in the experiments, it is beneficial to use foam static comprehensive evaluation index to unify the criteria of foam screening. Under the same condition of steam and foam injection parameters, compared with cold foam flooding,the oil production of unit foaming agent of hot foam flooding stays 24.4 percents higher. In the development of multi-layer co-injection and combined reservoir, start-up pressure of each layer is affected by foam injection pattern and permeability contrast. When injected with cold foam, the start pressure of each layer increases linearly along with the increase of permeability grade. But, for hot foam, this value increases in function of power. Because of permeability divergence, each layer’s contribution to the recovery percent is different,and to middle and low level permeability layers, foam has the similar producing degree. The optimized program of nitrogen-foam flooding is determined that the appropriate foaming injection mode is slug injection, and on the condition that the steam injection rate is 4.5 t/(d?m) and foaming agent mass concentration of 0.5%, the optimum injection volume is 0.01 PV; the optimum gas(steam)as(nitrogen) ratio is 20∶1; the optimum production factor is 1.3∶1 and the best foam spacing interval is 90 days.