The thick reservoir in China is in high water cut stage, and is flooded seriously now, in which the remaining oil is greatly dispersed accordingly. In order to clarify the distribution and influence factors of remaining oil in thick reservoir of point bar in meandering river deposit, and based on the internal configuration analysis of point bar, a fine geological model of point bar is constructed, then,the study on point bar reservoir is carried out by means of numerical simulation method and orthogonal experiment with single factor experiments. The results show that, the remaining oil is mainly distributed in the top of point bar, where the lateral accretion sandwich is blocked and the area between the wells where is not flooded; the remaining oil is overall dispersed and locally enriched. The dip, horizontal spacing, connectivity and curvature of the lateral accretion sandwich, water injection mode and well pattern will all have important impact on the distribution of remaining oil. The dip is smaller, the connectivity is poorer, and the horizontal spacing is greater, the development performance of the meandering river point bar reservoir is better. This paper has an important significance on further research of remaining oil distribution and potential tapping measures.