It is indicated that the deep overpressures exits in the northern of Dongpu depression, the rapid deposition and hydrocarbon generation are the two key control factors which result in diagenetic overpressure and hydrocarbon generation overpressure separately.The diagenetic overpressure is mainly developed in the deep sag area and others in transitional zone. The hydrocarbon generation overpressure is developed in the whole depression except for Huqing area in western fault zone. It is pointed out that the constrain effect on the thermal evolution of organic matter has 4 conditions, which includes threshold overpressure, early developed overpressure, good organic matter type and high original TOC content. The early developed overpressure significantly inhibits the thermal evolution of organics in the north part of Dongpu depression. Based on analysis of threshold value, the distribution and forming period of overpressure,this paper predicts the target zones which are inhibited by deep overpressure in the north part of Dongpu depression.