The rich resources of tight sandstone reservoir exist in Shengli oilfield, however, it is of the features of deep, fine, thin, poor and scattered distribution. The deployment of vertical wells on low productivity reservoir can only be of the characteristics of early rapid production decline with poor efficiency. In order to improve the level of development of tight sandstone reservoir, the horizontal well technology research and test are implemented through design and operation optimization to enhance the fast drilling technology for horizontal well, and obtain the break through for the tight reservoir productivity. In the field, we formed the horizontal well techniques with multi-stage fracturing by means of perfection of matching fracturing and completion pipes, field injection and storage equipment and fracturing monitoring approaches. Until the end of 2013, the Shengli oilfield has implemented 28 horizontal wells on the tight sandstone reservoir with the success rate of 94.4%, and cumulative production up to 50 746 tons of oil. It provides the reference for the effective development of tight sandstone reservoir in Shengli oilfield.