Integrated with analysis of seismic data, drilling data and logging data, this paper divided the Paleocene Lingshui formation into four third order sequence and established the sequence framework of Paleocene Lingshui formation in Qiongdongnan basin by using the principle and methods of sequence stratigraphy, sedimentology and petroleum geology. On the basis of the sequence framework,we analyzed the spatial distribution characteristics of each sequence. The results indicate that the development and evolution of the four sequences are characterized with inheritance and cyclicity in vertical. The depocenter which was in the northwest in the early stage moved to the south later. And, it was in the northwest again in the late stage. The deposition range of the basin varied during different stages. Different sag is of different deposition evolution feature. The distribution of the sequence is mainly controlled by the depocenter.Tectonic activity obviously controls the distribution of sedimentary strata. The thickness of the sequence is thick near the boundary fault in the each sag and becomes thinner in the gentle slope. Tectonic and sea level are the main factors controlling the development of the sequence.