Exploration and practice have confirmed that natural gas resources are abundant in Sulige, where large gas fields have been found in the north and east. However, gas exploration has no breakthrough in the southern area of Sulige. Based on large amounts of laboratory data analyses and using the method of mathematical statistics, the geologic conditions in the southern region of Sulige have been studied in detail including hydrocarbon conditions, reservoir properties, reservoir-cap portfolio allocation, migration carriers and accumulation conditions. It is revealed that the upper Paleozoic gas reservoirs in the Sulige southern area are favorable of geological conditions which are well-developed overlaying coal-bearing source rocks, large-scale banded sand body distributed from the north west to south east in the block, thick and far-ranging caprock and intermittent and direct caprock. Therefore, a perfect play (source-reservoirseal) of the upper Paleozoic in southern area of Sulige is likely to form under good conditions of accumulation and preservation as lithologic trap; effective carriers for gas migration and near-source lithologic traps can provide good conditions for gas accumulation and preservation. Reservoir evaluation showed that the southern area of Sulige has great exploration potential. Areas of Jingbian-Gaoqiao, Anbian-Wuqi, Anbian-Tiebiancheng and Yanchi-Jiyuan are favorable for future natural gas exploration.