There are no suitable technologies for the prediction of intra-salt mudstone fracture in the northern Dongpu depression.Based on the analysis of geology and geophysical characteristics of fractured mudstone reservoirs in the sag, it is concluded that the mudstone formations are easy to form tectonic fractures under tectonic deformation and with high content of brittle minerals. The geophysical characteristics of the fractured reservoirs are low-speed, low-impedance, low Poisson′s ratio and high resistivity etc. Accordingly, we proposed 2 fracture prediction technologies which are suitable for mudstone fractures of inter-salinastone overpressure and tectonic origin. The core technologies are based on residual structure analysis and generalized multi-attribute cluster analysis. The residual structural analysis technique considers conventional geological structure as three parts, namely, structure background, local tectonic deformation and random factor, and it highlights the changes of micro-curvature caused by local tectonic deformation which can be used in mudstone fracture prediction; the generalized multi-attribute clustering analysis technique combines seismic inversion meth?od and seismic attribute to achieve attributes optimization, and it uses neural network clustering analysis to predict the fracture zone in mudstone qualitatively. According to the practical application results, this 2 method had a good agreement. Based on the fracture prediction results, Pu-Shen 18-1 well in the Zhongyuan oilfield was drilled and has obtained a good oil and gas show in 10 sand group of Es3 at a depth of 3 258 m, and the daily oil production can reach 215-420 m3.