Water cut rises quickly in the middle and later periods of ASP flooding in Daqing oilfield, which leads to considerable discrepancies in development situations of reservoirs with different permeability and invalid injected liquid cycle. Aiming at these problems, the preparation of resisted alkali profile control agent in ASP flooding was carried out. Through choosing crosslinking agent and crosslinking agent concentration, polymer concentration and molecular weight and polymer maturing time, along with orthogonal experiment, the resisted alkali profile control agent formula fitting for ASP flooding was prepared. The formula was made up of polymer, ion crosslinking agent, organic crosslinking agent, stabilizer and deoxidant (polymer: molecular weight was 2 500×104 and its concentration was 2 000 mg/L; metallic crosslinking agent: YH-1 and its concentration was 0.15%; organic chromium: THM-1, THM-2 and their concentrations were 0.1%, 0.08% respectively; stabilizing agent: concentration was 0.2%; deoxidant: concentration was 0.1%). The gelation time was 102 hours and is adjustable. The viscosity after gelatinizing was 3 510 mPa?s. The stability time of gel was greater than 60 days. It had good salt resistance and small impact on interfacial tension of ASP system. When the profile control agent was applied to the process of ASP flooding, it can enable more injection liquid to displace low and medium permeable layer, and it can enhance oil recovery by 4% compared with that of ASP flooding without profile control agent. The numerical simulation results showed that the profile agent could keep better gelation performance by adding a small amount of pre-polymer slug before injecting profile control agent to achieve a better development effect.