The fractured vuggy unit of S80 is an important fractured zone in the Tahe oilfield, which stretch across the sixth and the seventh area. Methods based on petroleum geology, sedimentology and structural geology were used to study the S80 fractured structure model in detail. Sinkholes, river cave, tributaries cave and peripheral hole were found out. The sinkholes, river Cave, cave branch flow and peripheral holes mainly develop in the epikarst zone. And the sinkholes distribute along the structural low and the slope presenting a string of beads. A few peripheral holes were found out in seepage karst cave zones. River cave is the main part of runoff karst belt which grows parallel or nearly parallel to the direction of formation and superposed in the longitudinal direction. The deep seam and vuggy zone is characteristic of slit strip liking underground rivers, having close relationship with fault. High angle fractures, joints and pressure solution seam mesh were found in S80 unit which are controlled by the tectonization and influence the cracks and caves development in the epikarst. Therefore, limestone caves mainly grow in the surface layer of the karst belt with horizontal distribution. The deep seam cave zone has close relationship with the deeper fracture and exhibits underground river characteristics. In the Akekule and its adjacent areas, there are four important tectonic deformations which lead to the formation fracture development in S80 unit. During middle Caledonian, early and late Hercynian, the folding and faulting controls the crack growth and its direction in this area. Accordingly, the fractured-vuggy model of S80 wells in the fractured karst area was summed up into four stages: sedimentary and diagenesis, tectonic compression, uplift and dissolution, erosion expansion and back filling period, and the controlling factor of different periods on cave formation were proposed.