Chinese onshore oilfields have generally stepped into high water cut stage. A large number of wells shut down frequently for various reasons，which results in a damaged well pattern and poor reservoir development effect. It’s necessary to accurately reveal the influences of the well loss on the reservoir development effect so as to provide decision-making basis for well loss recovery measures. The loss percentage of reservoir recoverable reserves was defined and taking as an evaluation index of the reservoir development effect under the condition of well loss. The influences of well loss on the development effect in the high permeability reservoir were analyzed quantitatively. The results indicate that with the course of well loss time，the loss percentage of reservoir recoverable reserves increases first and then reduces for the relatively high permeability wells，and it increases for the relatively low permeability wells monotonously；at the same moment of well loss，the loss percentage of reservoir recoverable reserves for the relatively low permeability wells is greater than that for the relatively high permeability wells. Meanwhile，the impact of well loss position under heterogeneous permeability condition is obvious and that under homogeneous permeability condition is weak；at the same moment of well loss，with increasing plane variation coefficient of permeability，the loss percentage of reservoir recoverable reserves reduces for the relatively high permeability wells and increases for the relatively low permeability wells；the loss percentage of reservoir recoverable reserves of the production wells is higher than that of the injection wells with the same well loss percentage. Priority should be given to recover the production well.