KBM oilfield belongs to unconsolidated sandstone heavy oil reservoir. It is difficult to control the water cut and make oil production stable for the water cut rises quickly and the oil production declines greatly in the process of development. Efficient development measure should be taken through experimental research. According to the characteristics of the oilfield，combined plugging agents such as polymer water swelling and polymer gel were applied. During April to August 2013，a deep profile control experiment was made in the G and D layers of the oilfield central area. The average amount of the injected plugging agents is 2 187 m3 in each well. The results showed that the injection pressure raised by 1.5 MPa averagely. The injection profile was improved apparently：the swelling thickness of the main layers in oil well 420 raised from 5.5 m to 9.5 m and the swelling strength of the main layers dropped from 11.2 m3/m to 3.2 m3/m. The effect of oil production increases was obvious in the response producer：82.6% of the total 23 oil wells had good response. Composite water cut dropped from 88% to 83%. Accumulated annual oil production increased to 13 408 t. The effective period of the profile control and water plugging was more than 12 months long. The resistance factor rises to 3.26 based on the calculation and analysis. The formation flow resistance decreased obviously after profile control and flooding. A profile control system that fits for the unconsolidated sandstone heavy oil reservoir and has both effects of profile control and flooding is suggested to be optimized and used in the oilfield development.