Aiming at the problems of poor adaptability and stability of the conventional profile control agents in the hightemperature and high-salinity fractured reservoirs，a new kind of temperature-resistant and salt-tolerant profile control agent particles were synthesized by solution polymerization taking ammonium persulfate as initiator，acrylamide and dimethyl acrylamide 2 sodium sulfonate as comonomers，N，N-methacrylamide as the chemical crosslinker and hectorite as the inorganic crosslinker. The micromorphology and viscoelasticity of the agent were characterized. Shear-resistance property，swelling property，plugging property and EOR ability were evaluated. The results show that the profile control agent is a kind of irregular massive particles with initial average size of 66.87 μm. The particle size could reach to about 3.53 times of the initial size after 48 hours under the condition of simulated formation water and 75 ℃. The elastic and viscous moduli are 1 600 and 150 Pa respectively. The agent has good plugging property and the plugging ratio is all above 80%. The recovery efficiency may be enhanced by 20.1% after water flooding under the permeability ratio of 4.03. The profile control agent has better adaptability in the high-temperature and high-salinity heterogeneous fractured reservoirs.