Guided by theories of reservoir engineering，physical chemistry and organic chemistry，by means of instrumental analysis，chemical analysis and physical simulation，taking reservoir and fluid of Daqing oilfield as research object，experiments have been carried out considering evaluation indexes of viscosity，rheological property，viscoelasticity，interface property，molecular coil size，state of molecular aggregation and injection pressure of salt-resistance polymer-surfactant solution，so that polymer-surfactant can be more suitable for the reservoir. Results show that the minimum concentration of β-cyclodextrin that is needed to completely inhibit the association of polymer-surfactant molecules is 0.065% under the condition of sewage or clean water from Daqing. With the increase of the concentration of β-cyclodextrin，the association of the molecular chains of the polymer-surfactant became weaker and the branch connected each aggregation became thinner，thus the molecular configuration presented a kind of loose branching structure. This resulted in the drop of viscosity and the loss of viscoelasticity. With the increase of the concentration of β-cyclodextrin，the molecular coil size of the polymer-surfactant solution decreased as well as the compatible pore throat size，which resulted in a wider permeability scope.