Preponderance flow path（PFP）leads to inefficient cycle，even invalid cycle of injected water between injection and production wells，which seriously affects the effect of waterflooding. This is the key problem to improve waterflooding recovery for middle and high permeability sandstone reservoir. For the actual oil production，the dynamic data were mined in maximum degree，and the seepage theory and mathematical methods were applied in identification and description of the PFP. Based on coring well data，seepage partition was determined and PFP between injection and production wells was identified combined with numerical simulation technology. According to invalid cycle model，high velocity non-Darcy flow equation and Carman-Kozeny equation，the parameters of PFP between injection and production wells were quantitatively described，and those in well pattern were calculated using fuzzy set theory. Taking the typical well pattern of thick oil layer in P23 delta front in the Xingliuzhong area for example，the PFPs between Well X21 and Well X11，Well X24 and Well X13 and Well X26 and Well X14 were identified respectively，and the invalid cycle volume，average pore radius and permeability were calculated，which are in good agreement with the actual，and thus the accuracy of the proposed method is verified.