In order to analyze the effect of lithology on in-situ combustion better and to improve its recovery efficiency，advance mechanism of in-situ combustion front and composition changes of output must be understood clearly. One dimensional simulation model of the in-situ combustion was applied to study the effect of sandstone and glutenite on front advance distance，front advance rate and peak temperature of the in-situ combustion under different gas injection pressures or gas injection flow rates，as well as the content and composition of produced liquid，gas and residual oil sands and their variation patterns. The results show that as the gas injection flow rate and pressure increased，the front advance distance in the glutenite is longer than that in the sandstone，while its advance rate and peak temperature is lower than that in the sandstone；liquid and oil produced from the glutenite is more than those from the sandstone，and except under lower pressure or flow rate，the proportion of low-carbon number saturated hydrocarbon in the produced liquid of the glutenite is relatively high，while that of high-carbon number saturated hydrocarbon in the produced liquid of sandstone is relatively high. When the gas injection pressure is below 2.0 MPa，the proportion of aromatic hydrocarbon in the produced liquid of the sandstone is relatively high，while that of aromatic hydrocarbon in the produced liquid of the glutenite is relatively high when the gas injection pressure is above 2.0 MPa. In flow experiment，the proportion of aromatic hydrocarbon in the produced liquid of the glutenite is higher than that in the produced liquid of the sandstone. Experiment results of elemental microanalysis and infrared spectra analysis show that organic element content of the residual oil sands in the glutenite is higher，and colloid and asphaltine is more likely to be driven out of the glutenite. Considering various factors，glutenite reservoir is more suit? able than sandstone reservoir for the in-situ combustion.