Reservoir development of Liuhua reef limestone is complex，and its heterogeneity was very strong in the Pearl River Mouth Basin. Based on seismic，well logging，sedimentary and geological data in A Oilfield，the impact of sedimentary microfacies，interlayer，physical properties and seepage dynamic information of the reef limestone on the reservoir heterogeneity was analyzed，and then the reservoir heterogeneity was evaluated quantitatively under conditions of sedimentary facies constraint using the entropy weight method，and a stochastic model of the comprehensive reservoir heterogeneity evaluation was established under different constraint conditions. The results show that this method can quantitatively characterize reservoir quality parameters and reservoir geometry parameters. According to the result of comprehensive evaluation of reservoir heterogeneity and reservoir dynamic data，the distribution of remaining oil potential area is predicted in the area with heterogeneous synthetic index 0.5-0.7，and the remaining oil is mainly enriched in the northwest wing，southeast wing and the structural high position near the fault. Nine horizontal wells were deployed in the predicted potential areas where the average daily oil output was at least 50 m3/d higher than that of the ODP design production. And the average water saturation increased relatively slow. The potential areas had longer stable time for daily production. The predicted results evaluated by entropy weight method match well with the actual spatial heterogeneity of reservoir.