The marine sandstone reservoirs are characterized with strong energy of edge and bottom water. Conventional experimental standards barely reveal reservoir percolation characteristics under high oil recovery rate after high intensity water flooding. The experiment process of the high-multiple water drive was improved based on sealed coring data of Xijiang 24-3 Oilfield. The actual situation was simulated after water injection multiple was increased from conventional 30 PV to 2 000 PV. The variation of physical properties and remaining oil in marine sandstone reservoir after high-multiple water drive were analyzed systematically from six aspects，including mineral composition，pore-throat structure，wettability，oilwater relative permeability curve，residual oil saturation and oil displacement efficiency. Therefore，the characterization method and numerical simulation method were established for obtaining the ultimate displacement efficiency of this type of reservoir. The results show that microscopic pore-throat structure and mineral composition both change after the high-multiple water drive，which has an impact on the wettability and relative permeability curves as well as the residual oil saturation and oil displacement efficiency. The change of physical properties of the oil reservoir is favorable to oil displacement，the residual oil saturation dropped obviously and the oil displacement efficiency was enhanced obviously.