The study of charged molecular membrane system for sand consolidation was carried out to solve the problems oflow benefit of mechanical sand control and serious damage to reservoir caused by conventional sand consolidation agents in unconsolidated sandstone reservoir in Hekou oil province. The charged polymer 2012A001 was selected as the main agent of the charged molecular membrane system for sand consolidation. The reaction mechanism of sand consolidation system controlled by pH value was emphatically analyzed. The effects of different reservoir conditions on sand consolidation were investigated. The results show that the erosion resistance flow rate of the charged molecular membrane system for sand consolidation is up to 6 000 mL/h. When the temperature exceeds 40 ℃ and the salt content in water is below 10 000 mg/L，the curing speed of the charged molecular membrane system increases with the increase of temperature and salt content. The higher the clay content is，the lower the permeability retention of the core will be. The clay stabilizer should be added when the clay content exceeds 5%. The oil on the surface of sand particles will affect the adsorption of the charged molecular membrane system，so it is necessary to wash the oil thoroughly before injection. The sand control performance is improved with the decrease of sand particle size and the increase of polymer mass fraction but the permeability damage would be more serious. Therefore，the reasonable mass fraction of the charged molecular membrane system for sand consolidation should be selected according to the sand particle size of the reservoir in specific block. According to the characteristics of unconsolidated sandstone reservoir in Hekou oil province，the charged molecular membrane systems for sand consolidation with different formulations were developed. Since 2018，this system has been applied in 15 wells in Hekou oil province，with a cumulative increased oil production of 4 500 tons oil and an input-output ratio of 1∶6.