Foam flooding，as an effective way to improve oil recovery，has been widely used in major oil fields in China. It is found from numerous field applications that suitable injection parameters can give the fluidity control ability of foam flooding to full play. APG-10 was selected as foaming agent，DG as foam stabilizer，and natural gas as gas phase to prepare natural gas foam. Orthogonal experiments with regards to mass concentration of foaming agent，mass concentration of foam stabilizer，injection flow rate of natural gas foam，volume fraction of natural gas foam，and oil saturation were designed to determine the optimal formula of natural gas foam system and the best injection parameters. The influence of different factors on the fluidity control ability was analyzed. The standard deviation was introduced to describe the fluctuation range of the resistance coefficient during the displacement. Further，the adaptability of optimal injection parameters in formations with different permeability was explored. In the porous media with a permeability of 100 mD，the optimal injection parameters were 6 000 mg/L APG-10+400 mg/L DG. When the volume fraction of natural gas foam was 70% and the injection flow rate of natural gas foam was 4 mL/min，the fluidity control ability of natural gas foam was the strongest and the resistance coefficient was 57.04. In the study of permeability adaptability，when the permeability of porous media was within 3 000 mD，the fluidity control ability of natural gas foam grows as the permeability increases.