After several cycles of steam huff and puff development，the oil-steam ratio of heavy oil reservoirs decreases significantly and the number of ineffective and low effective wells increases，which causes worse economic benefits. It is urgent to explore the transformation development technology of heavy oil after multiple rounds of huff and puff. As the existing chemical cold production additives cannot meet the requirements of viscosity reduction and oil displacement under a low dynamic in field，a comb-shaped amphiphilic permeable agent PDE-1 for viscosity reduction and oil displacement was synthesized in this paper. Specifically，the effects of polymerization conditions such as the initiator dosage，and monomer ratio on the performance of PDE-1 were investigated by single-factor experiments. In addition，the technical means such as the optical microscope and microfluidics were applied to analyze the performance of PDE-1，including the penetration and depolymerization，wettability，viscosity reduction，and static oil washing. The results revealed that for the synthesis of PDE-1，the optimal monomer ratio should satisfy that acrylamide：sodium acrylate：functional monomer BBAM：monomer containing ether bonds equals 75∶20∶1.5∶3.5，with the initiator dosage of 0.3%，polymerization temperature of 40 ℃，total monomer mass fraction of 25%，and reaction time of 6 h. The synthesized PDE-1 can spontaneously permeate and depolymerize heavy oil under a low dynamic in reservoirs，change the rock wettability in the capillaries，and turn the reservoir capillary resistance into oil displacement power. At the mass concentration of 1 500 mg/L，the viscosity reduction rate of PDE-1 in ordinary heavy oil is 97.5%，and at 500 mg/L，the oil washing rate of oil sand reaches 58.7%，which indicates that PDE-1 has excellent viscosity reduction and oil washing performance.