The heterogeneity and viscous fingering are the key factors to determine the development effect of CO₂ flooding.The adjustment of injection-production modes is an effective means to control gas channeling and expand the swept area.At present，research on the above directions mainly focuses on the numerical simulation. Therefore，it is urgent to carry out physical simulation research on different injection-production modes of CO₂ flooding，so as to further clarify the production mechanism，development characteristics，and reservoir adaptability of modes of CO₂ flooding such as continuous gas injection，rotation production，and injection-production coupling. In this paper，the development characteristics of these modes were compared through similar physical simulation experiments of CO₂ flooding，and the applicability of different injectionproduction modes of CO₂ flooding was analyzed. The results show that the development effect in areas with different permeability is different under the continuous gas injection，and the potential for enhanced oil recovery after gas breakthrough is very low in low-permeability areas，so CO₂ continuous gas flooding is suitable for developing relatively homogeneous reservoirs. For the rotation production mode，the directions of the mainstream line between injection-production wells can be changed by opening production wells alternately，so as to effectively improve the development effect of low-permeability areas in heterogeneous reservoirs. Therefore，this mode is suitable for strongly heterogeneous reservoirs or the development adjustment stage after gas channeling. The injection-production coupling mode can expand the swept area of the whole reservoir in a more balanced way by alternating injection-production to cause alternating changes in the pressure field，so as to improve the reserves producing ratio in the corner area of the reservoir. Therefore，it is suitable for weak heterogeneous reservoirs or the initial development stage.