Nandan-Liuzhou area of Guangxi Province is located in Guizhong Depression. The platform basin facies with the primary lithology of siliceous mudstone and the platform shelf facies with the primary lithology of calcareous mudstone are widely distributed in the area， which together constitute a set of the Devonian dark shale series. Based on the analysis of typical field profiles and geochemical data， it is concluded that the Middle Devonian source rocks mainly dominated by dark muddy shale of Luofu Formation of the Middle Devonian Series have superior shale gas accumulation conditions. The maximum thickness of the source rock can reach 600 m； the TOC value is 0.61%-3.60%； the R_o value is 2.55%-3.63%， and it is in the high to over-mature stage and has great hydrocarbon generation potential. The porosity is 1.7%-2%， and the average permeability is 0.11 mD， indicating an extremely low porosity and low permeability reservoir. Its average clay mineral content is 41.6%， and its average brittle mineral content is 59%，belonging to a high-quality shale gas reservoir. The cap rock and roof-to-floor conditions of the study area are good， and the local structural deformation is weak， offering great preservation conditions. The comprehensive study shows that the west of Huanjiang-Yizhou area is a favorable area for Devonian shale gas exploration in the study area.