Because of difference of physical property, alternation of deviation angle, friction loss in horizontal bore hole,the development within the horizontal interval is not balanced. According to the fluid mechanics in porous medium and reservoir engineering,the model of horizontal well fluid mechanics, turbulent flow model of eyehole and hole model of horizontal well are built in different reservoir. Meanwhile, the damage factor during drilling and damage factor during perforating are introduced into the new model. According to the mass conservation equation, flow couple model of reservoir and horizontal well hole are built. The effect of deviation angle, permeability, distance to bottom water, and viscosity to liquid producing balancing profile of horizontal well is analyzed by the model. By optimizing the perforation model of horizontal well, variable density perforation can achieve the liquid balancing producing for horizontal well hole. It was demonstrated that, compared to the previous horizontal well, the water cut rising is slow, and the production performance become better. Thus, variable density perforation of horizontal well is the new technique for enhance the reservoir balancing production.