Natural fractures are developed in deep tight sandstone gas reservoirs in Kuche Depression of Tarim Basin，which are in the enclosed environment with high temperature，high pressure，and high crustal stress. Formation water has high salinity and local ultra-low water saturation. Some gas wells often encounter sand production to different extents，which seriously disturbs the normal production of gas wells. A sample of deep tight sandstone gas reservoir in Tarim Basin was selected in our experiment，in which the dry-wet alternation of the rising and falling of water saturation was simulated and the changes in dynamic mechanical parameters and stress sensitivity coefficient of rock were monitored. The results show that for the rock samples of deep tight sandstone gas reservoirs，the dynamic Young’s modulus and Poisson’s ratio take a dive after dry-wet alternation. The stress sensitivity coefficients of base rock samples and fractured rock samples are respectively 0.50-0.89 and 0.43-0.45，indicating their moderately weak-strong and moderately weak stress sensitivity. According to analysis，in gas drilling（drying），the release of formation pore pressure could change near-well stress，and the crystal stress caused by salting-out and fracture surface of gas washout could reduce rock strength and induce sand production. In well completion after gas-liquid conversion（dry-wet alternation），the water absorption and dehydration of clay minerals caused by dry-wet alternation，acid denudation，frictional sliding of fracture surface and change in water saturation as well as the spalling of sand grains from fracture surface by spheroidal weathering could reduce rock strength. Sand grains falling off the fracture surface will support the fracture and reduce its stress sensitivity. In the development of deep tight sandstone gas reservoirs，dry-wet alternation rounds and liquid intrusion should be reduced. The inevitable liquid should be drained back in time to prevent it from reducing rock strength. Fiber should be added in fracturing to avoid proppant reflux. At the same time，sand production should be controlled with reasonable sand production measures and sand control technology of wire-wrapped screens.