In order to study the relationship between tectonic stress field and migration and accumulation of oil and gas in Damintun depression, and based on the features of geology and tectonic stress field in the area, the three-dimensional tectonic stress field finite element model of the block is established. The contour maps of maximum principal stress, minimum principal stress and maximum shear stress of the target zone are obtained through analysis of numerical simulation. Based on that above, the oil and gas enrichment zones are forecasted by the theory of oil and gas migration. The results show that: under the effect of tectonic stress field,the direction of migration and accumulation of oil and gas is from high areas to low areas in tectonic stress field, and from high potential areas to low potential areas in fluid potential field. The favorable zones are low value areas of tectonic stress, low potential areas of fluid potential field, and the oil and gas across the trap near fracture zones. High-yielding wellblocks are consistent with low value areas of tectonic stress field and fluid potential field through the comprehensive analysis of actual capacity of drilled wells and forecast results, which provides scientific basis for the prediction of enrichment zone for oil and gas and deployment of favorable drilling wells in the area.