In view of some restrictions of application of pre-stack seismic inversion to hydrocarbon detection, application of prestack seismic inversion to predicting hydrocarbon for conglomerate body in Minfeng area is suggested. Firstly, the parameters of interest interval including density, compressional wave velocity, shear wave velocity and Poisson’s ratio are calculated by means of analyzing geophysical signature. Secondly, the seismic response characteristics for gas bearing reservoir in pre-stack gather are analyzed by forward modeling. Lastly, based on intersection analysis methods, the applicability of parameters such as intercept-gradient, velocity-density,Lambda constant, velocity-Poisson’s ratio to hydrocarbon detection is correlated and Lame’s constant and Poisson’s ratio which are sensitive to hydrocarbon in interval of interest are selected as inversion parameters. The ability of sensitive parameters to locate the gas bearing reservoir is analyzed through prestack seismic inversion. The application results indicate that the research results acquired by intersection interpretation of lambda constant and shear modulus extracted from pre-stack seismic inversion coincides with drilling test results, and predicted favorable gas-bearing area of 109 km2, natural gas resource of 290×108 m3.