Aiming at the development contradiction of severe water breakthrough in Anpeng area of Zhao’ao oilfield，the gel foam is selected，including the high temperature resistance foam bubbling agent and the gel foam stabilizing system which is made up of 0.2%-0.3% foaming agent，0.25%-0.35% comb polymer and 0.6%-0.8% phenolic resin crosslinker.The gel foam profile control system is developed，the injection mode，gas-liquid ratio and injection rate are optimized by the physical simulation methods and the high temperature resistance gel foam system adaptable to the high temperature reservoir of Zhao’ao oilfield is developed.The results indicated that the phenolic resin cross-linked polymer has good effect for stabilizing foam as the stabilizing system of the gel foam and could increase the half-life period substantially.Compared to the slug injection mode，the gas-liquid mixed injection mode has better plugging performance；the best gas-liquid ratio is 1∶1，and higher or lower all has an adverse effect on the plugging performance of the gel foam；the best injection rate is 0.5 mL/min，higher or lower also has the same adverse effect on the resistance coefficient and plugging performance of gel foam.The displacement experiment shows that the gel foam profile-control system has good selective plugging performance，which could increase the profile improving rate to 99%，and could increase the oil production by 44.6%.