Inflow performance and optimization of artificial lifting way for horizontal wells in low permeability reservoir is the key to develop the horizontal wells for low permeability reservoir. Based on the classic Giger capacity formula, and adopting the hydropower similar principle and conformal mapping method to derive the productivity model and inflow performance equation of the hypotonic non-Darcy horizontal wells, the model has a higher accuracy after the field application verification, and the capacity influencing factors sensitivity of horizontal wells in low permeability reservoir is then analyzed. The analysis indicates that the horizontal well inflow performance variation is basically not affected by starting pressure gradient; and keeping pressure is the key to improve the efficiency of low permeability horizontal wells, the starting pressure gradient, permeability and coefficient of variation of the viscosity of the fluid are inversely proportional to liquid production, and the lower the pressure, the more obvious the effect; for the horizontal section length within 400 m, the ultimate production increases linearly with the horizontal length, the production drops and finally stabilized beyond 400 m;we use the equivalent weighting method and analytic hierarchy process to establish the lifting way preferred model, and the best lifting way of field wells is the electric submersible pump lifting.