In-situ combustion is one of the effective methods used for heavy crude oil. The reservoir heterogeneity is bound to affect the development performance. Three kinds of heterogeneous model including permeability, thickness and geometry form are proposed based on the distribution characteristics of the sedimentary micro-facies of certain reservoir. Then, 18 reservoir simulation models are built by applying the method of reservoir numerical simulation. The development effectiveness of injection-production pattern caused by heterogeneity is studied. The research result shows that the initial and cumulative production is different due to different injectionproduction pattern at the same condition. In order to improve the development effectiveness of in-situ combustion, the injection-production pattern should be optimized. And, the impact of geometry form is the biggest, thickness secondly, then the permeability.