In order to study the production stimulation mechanism of water flooding by multi-stage fracturing horizontal well, the electrolytic simulation experiment of fractured horizontal well is designed according to the water and electricity resembling principle, and the pressure distribution and the productivity influence factors are studied. The experiment results show that the pressure contour is distributed in parallel in the middle of horizontal which has the fracture, and the fluid flow is unidirectional, it shows that the multi-stage fracturing horizontal well can improve the fluid flow characters and decrease the percolating resistance. The horizontal productivity can be enhanced by increasing the horizontal penetration ratio, the fracture numbers and penetration ratio, the angle between horizontal and fracture. The best parameters are as follows: the horizontal penetration ratio is 0.8, the fracture numbers are 6 (the space between fractures is 91 m), the fracture ratio is 0.25, the angle between the fracture and the horizontal section is 90 degree. The well pattern is staggered line-drive well network, and the ranges of those parameters which have effect on the productivity are 0.032, 0.024, 0.018, 0.018 and 0.004. The field application showed that the productivity of multi-stage fracturing horizontal well is 2 times than that of vertical well, and it is the effective development style for low permeability reservoir.