Considering the actual conditions of irregular well pattern and heterogeneity in reservoir, and based on the reservoir engineering theory, a method to predict the residual oil distribution and dynamic development indexes has been proposed herein. The method first splits the oil field into multiple units dynamically and the units can be equivalent to homogeneous one, so that, we can use the Buckley-Leverett waterflooding theory to predict the dynamic development indexes of every unit and then calculate the entire reservoir development indexes. Compared with the numerical simulation method, the new procedure runs more quickly and requires less computer memory. The analysis on the application of theory above in an oil reservoir with 16 wells shows that the results of the method are basi?cally consistent with the numerical simulation method, which is of significant value for field application.