In order to improve the reserve utilization and petroleum recovery of low permeability reservoir, we summarized the study results of Boxing low permeability reservoir and other related information; in the way of combining theoretical research and laboratory experiment, we studied percolation mechanism of the low permeability reservoirs. According to the corresponding percolation character of low permeability reservoir with different permeability grades, ordinary low permeability, extra low permeability and super low permeability are divided. For the extra low permeability and super low permeability reservoirs which are difficult to exploit, various differential development techniques such as normal water-injection, small well-distance water-injection, large-scale suppression with no waterinjection,gas-driving method and irregular method of long-distance level well exploitation were adopted, which have achieved promi? nent technical progress. We also evaluated the suitability of the technique used in low permeability development. We propose that the fluid in the low permeability reservoir is possessed with certain flowing ability, and all of the low permeability reservoirs could be exploited efficiently by using differential development technique to improve the percolation condition.