The majority of remaining non-producing reserves in Daniudi gas field are Ⅱ-Ⅲ low-grade reserves, and horizontal well development will be the primary way for gas field productivity construction. Therefore, the optimization study on the multi-stage fracturing development technology policy of horizontal well is extremely significant. Based on numerical simulation model of multi-stage fractured horizontal wells, the paper investigated single well design, pressure cracks, well pattern and well spacing. The study eventually demonstrates that the extending direction of single well horizontal section should be perpendicular to the maximum principal stress direction. Horizontal section is better to be located in the middle of gas reservoir. Crushed fractures crossing gas-bearing sand body with a crenellated distribution are optimal. When average half- length of the fracture is 158 meters and average fracture spacing is 112 meters, row-interleaving well patter is optimum. Combined with numerical simulation method, dynamic analysis method and economic evaluation method, it is suggested that the reasonable well spacing in Da98 well area ranges from 1 000 meters to 1 200 meters, and well array spacing is 700 meters.