The sequence of non-coastal fluvial facies stratum which developed in continental basin of China is not controlled by the sea level eustacy. Therefore the cosatal fluvial facies sequence stratigraphic model is no longer applicable. This calls for a new fluvial facies sequence model which is not affected by sea level eustacy. This paper, with references to the domestic and foreign research results of fluvial facies sequence stratigraphy, combining with spatial combination styles of fluvial sedimentary system and the controlling factors of river types, following the principles of sequence stratigraphy and sedimentology，summarized the major controlling factors of non-coastal fluvial sequence. Considering the study of the sedimentary patterns of the Neogene in Jiyang depression, the non-coastal fluvial facies sequence stratigraphic model was discussed and established and its potential resources distribution was pointed out. The development of non-coastal fluvial sequence is mainly controlled by tectonic subsidence, sediment supply, topographic slope and climate. Non-coastal fluvial facies sequence may exist initial system tract，growth system tract and decline system tract. When differential uplift of the basin basement occurs，uplifting system tract may also occur.