Huzhuangji area in the west slope of Dongpu depression is complex in structure with frequent alternation of sandstone and mudstone. Sandstones and faults are configured to form a complex oil and gas carrier system, which has great influence on oil and gas migration and accumulation in this area. This paper focuses on the relationship between the carrier systems and the hydrocarbon distribution in Hu5 block area of Huzhuangji oilfield. The analysis results show that: oil and gas generated from the source rock in the east sag of Huzhuangji oilfield migrated nearly east-west to the slope and accumulated; the thickness of sand body and the fault distance control the lithology contraposition of the two sides of the fault, thereby affecting lateral fault sealing. Two types of carrier system that consist of different sand body and fault combinations were analyzed and their control on the hydrocarbon migration and accumulation in this area. For faults parallel to the strike of the main fault, they are favorable for oil and gas migration if their fault distance is small combining with thick sandstones; and they are favorable for oil and gas accumulation if their fault distance is large enough to disconnect the thick sand bodies; and for faults oblique crossing the main fault, it is favorable for oil and gas migration where the fault distance is small and sand body is thick; and tis favorable for hydrocarbon accumulation where the fault distance is large and sand body is thin.