The potential of hydrocarbon accumulating in drape structure on the uplift in Neogene differs with uplifts，which is the main reservoir type in Zhanhua sag. Using drilling and geophysical data，the relationship between uplift belt rotationshearing movement and oil and gas accumulation of Neogene in Zhanhua sag was studied through analyzing the regional geological mechanics，the fault rotation-shearing characteristics and hydrocarbon reservoir. The research results show that Zhanhua uplift sheared and rotated to the right clockwise induced by the dextral strike slip of Tanlu faulted belt and the weak regional NE-SW compressional stress field duing Neogene. Under the rotation-shearing action，the faults，locating on the left side of uplift（North for the reference direction），twisted and opened to make a dominant pathway for hydrocarbon migrating or accumulating. The faults，locating on the right side of uplift，are characterized by compress-shear properties which are unfavorable for oil and gas vertical migration. The drape structures of Neogene on the left side of the uplift（dominant pathway）are easy to form large-scale oil and gas reservoirs. The faulted zone on the left side of the uplift is favorable for subtle reservoir exploration in Neogene for the next step.