The 3D basin modeling technique was used to restore the geohistory evolution process of Middle-Upper Yangtze area. Based on geological development characteristics，the control of paleo-tectonic on sedimentary was analyzed to point out its geological significance for hydrocarbon generation. The results show that depressions and uplifts developed alternately in the Yangtze area before Devonian sedimentary period，and an uplift and two depressions of north-east striking developed in Yangtze platform during Indo-Chinese epoch. Through comparing the structures developed in the Caledonian period and in Indo-Chinese epoch，Chuanxi depression developed in Indo-Chinese epoch locates on the Leshan-Longnüsi uplift developed in the Caledonian period. Luzhou paleo-uplift developed in Indo-Chinese epoch superposes on the Chuannan depression developed in the Caledonian period. The zone of Nanchong-Liangping locates in structure transform regions and the Shishou-Yichang uplift develops in north depression of Jianghan Basin，which suggests that the Caledonian strata reversed strongly in Indo-Chinese epoch. The Caledonian structures superposed and reversed strongly in Indo-Chinese ep? och showing by the east-west and the north-south structural evolution profiles crossing the whole Sichuan Basin.The Luzhou paleo-uplift，superposed on the Caledonian paleo-depression developed in Indo-Chinese epoch，is a typical uplift which could accumulate hydrocarbons generated from the Silurian source rocks below. It could form favorable reservoirs and has good exploration prospect. The Leshan-Longnüsi paleo-uplift and the Qianzhong paleo-uplift are the areas that receive the charge of hydrocarbons coming from the source rocks below until the Indo-Chinese epoch，but they only control the accumulation of the Cambrian hydrocarbons underlying the Ordovician. The paleo-slope adjacent to the hydrocarbon generation depression of the Cambrian source rocks is the benefit zone for hydrocarbon exploration.