For efficient recovery of offshore heavy oil，amphiphilic polymer with better emulsification and solubilization behavior for heavy oil was developed. Core physical simulation method was applied to evaluation on injectivity，mobility control，recovery efficiency of the amphiphilic polymer. The amphiphilic polymer shows good injectivity in offshore high permeability sandstone reservoir，and the best mobility control and the highest recovery efficiency：1 000 mg/L of amphiphilic polymer solution has a resistance factor of 201 and a residual resistance factor of 115. Viscosity reduction polymer has better interfacial activity，poorer mobility control，and similar displacement effect as ordinary polymer，whose recovery efficiency is 90.13% in homogenous cores and only 33.76% in heterogeneous cores. Experiment results show that the amphiphilic polymer in one-dimension homogenous core experiment is suitable for the profile control agent controlled by small-slug mobility and that in constant-pressure oil displacement experiment may slow the trend of oil production decline with water flooding. Three times of pore volume of ordinary polymer and amphiphilic polymer were injected cumulatively in oil displacement experiment with three-layer heterogeneous cores and their recovery efficiencies were 32.73% and 54.45% respectively. The amphiphilic polymer with better mobility control and emulsification ability shows great potential in chemical flooding of the heterogeneous heavy oil reservoir.