Secondary hydrocarbon generation of the Carboniferous-Permian coal-measure source rocks underlying Bohai Bay Basin since the Paleogene becomes petroleum research focus of eastern China for its great significance of oil-gas accumulation. With literature review on its distribution and geological characteristics，investigation methods and models of secondary hydrocarbon generation about the source rocks，initial point，kinetic mechanism and effectiveness evaluation are concluded as the crucial issues on secondary hydrocarbon generation research of the Carboniferous-Permian coal-measure source rocks. Moreover，the tectonic evolution analysis and geochemistry evolution reconstruction are suggested to determine the initial point of secondary hydrocarbon generation. Based on different initial point of secondary hydrocarbon generation，thermal simulation experiments should contribute to imply the properties and hydrocarbon generation kinetic mechanism of organic matter during secondary hydrocarbon generation processes. Combining with temperature and pressure conditions of different structural units，resources of secondary hydrocarbon generation is predicted to evaluate petroleum sources of deep horizons.