The fracture initiation and propagation of hydraulic fracturing are important to post-fracturing performance of tight oil and gas reservoirs. Based on uniaxial compression experiment results of rock specimens taken from tight sandstone reservoir at 3 200 meters depth in certain block of Shengli oilfield，rock mechanics parameters used in the numerical simulation of uniaxial compression experiment were calibrated，and the effect of brittleness index and residual stress on hydraulic fracture propagation was investigated by using numerical simulation software RFPA2D. The results show that higher brittleness index is more favorable for hydraulic fracturing propagation，and hydraulic fracture with larger width and smaller initial stress can lead to larger area of effective complex fracture network and better hydraulic fracturing effects. When the residual stress is lower，the degree of development of hydraulic fracture is higher with wider fracture width and smaller initial stress and the effects of hydraulic fracturing are better.