Amu Darya Basin is an exploration area with huge potential of natural gas. It is known as the most important source of Mid-Asian nature gas pipeline. There is still a shortage in research of reservoir forming rules even though many researches have been carried out in recent 10 years，and controlling factors for gas reservoir forming are also uncertain. In order to find the next gas reservoir target in the further exploration，a series of comprehensive analysis was conducted. It focused on the main controlling factors that led to various types of gas reservoirs. Using a combination of geophysical data interpretation，gas reservoir accumulation analysis，trap evaluation，sedimentary facies analysis，reservoir evaluation and single well production capacity analysis，etc.，the research concluded the main controlling factors of gas accumulation from two aspects-structure and sedimentation. The former includes basement paleo-uplift which controls the trap distribution，faults which are pathway for hydrocarbon migration and tectonic movement since Neogene that results in hydrocarbon redistribution. The latter includes anhydrock and salt shelter which is necessary for the trap of effective hydrocarbon，reef-beach bodies which are closely related to high-production gas well and reservoir type which determines gas-water interface and types of gas reservoirs. The distribution of each type of gas reservoir is determined by one or several main factors，forming bulklike gas accumulation and stripped distribution.