The surfactants with good CO2 foam performance were screened out by high-pressure and high-temperature visualized foam device. The solubility of the systems in supercritical CO2 were evaluated by using alcohols as co-solvents. The ability of EOR of CO2-soluble surfactant foam was tested by high-temperature and high-pressure core displacement experimental device. The results show that the selected nonionic surfactants N-P-12 have good CO2 foam stability at high-temperature condition of 125 ℃，and the addition of alcohol as co-solvents could significantly increase the solubility of the surfactants in the CO2. During the CO2 foam flooding，the resistance factor may increase first and then decrease，and the generated foam may play the role of mobility control in the system. Moreover，CO2 foam based on CO2-soluble surfactant is more efficient on enhancing oil recovery than the conventional CO2 foam，and the ultimate oil recovery is raised up to 92.50%.