The deep and ultra-deep reservoirs have high formation pressure，and the unreasonable parameter control during the development process can easily lead to sanding，casing damage，and cement plugging in oil wells. Determining a reasonable production pressure drop is the key to the effective use of the reservoir. Taking Yongjin Oilfield as an example，through preliminary oil test and trial production analysis，it is believed that improper production pressure drop control and inadequate understanding of asphaltene precipitation are the key factors that have prevented the oilfield from being developed economically for years. Mature software is used for sand production prediction，and wellbore pressure calculation is carried out，in order to seek a reasonable working system. The reason and prevention method of asphaltene precipitation are studied by experimental methods. The results show that the critical production pressure drop of the formation in the study area is 34.9 MPa. During the preliminary oil test，trial production perforation and production，the pressure drop exceeded the critical production pressure drop and resulted in sand production. The crude oil system is unstable，and the CI value is 2.33.The wellbore pressure is lower than the asphaltene stable pressure，which leads to asphaltene precipitation and plugging.The analysis shows that this is the main reason for the poor early development effect. Based on this，the development strategy for the whole process of pressure control is determined from the opening of the oil and gas layer. When the formation pressure is high，the reasonable pressure controlled production can solve the problems of sand production and asphaltene precipitation. When the pressure drops，asphalt dispersant is added to assist production. Two wells have been tested and all have been successful.