The lower sand member of Paleogene Kumugeliemu Group in the margin of Wensu Uplift-Yingmaili Uplift area in Tarim Basin has become the focus for lithologic reservoir exploration in recent years，and the massive oil and gas has been produced from Well Yudong1 Block. However，the high-resolution sequence stratigraphy characteristics，sedimentary microfacies types，and temporal-spatial evolution laws were not yet clear. Based on core，drilling，logging and 3D seismic data，the markers，sequence interfaces，and flooding surfaces which can be isochronally tracked and compared were identified. A high-resolution sequence stratigraphy framework was constructed，under the constraint of which the types and characteristics of sedimentary microfacies of each high-frequency sequence unit were analyzed and the temporal-spatial evolution laws of sedimentary microfacies were revealed. The results show that the lower sand member of Paleogene Kumugeliemu Group is the ascending half cycle of the third-order sequence ESQ1 and can be divided into four parasequence sets，namely sand member 4，sand member 3，sand member 2，and sand member 1 from bottom to top. The sedimentary period of the lower sand member of Paleogene Kumugeliemu Group is characterized by gradually deeper lake water and bigger lake basin，thus resulting in“water progradation and sand retrogradation”. Three types of sedimentary facies such as fan delta，braided river delta，and lake are developed here，in which the sediment period from sand member 4 to sand member 3 features the lowstand system tract with small accommodation space，adequate source supply，and slowly rising lake level.Large deltas are developed in the source areas of Wensu Uplift and Yingmaili Uplift and large near lakeshore sand bars are developed in Yingmaili Uplift source area. The sediment period from sand member 2 to sand member1 is featured by the transgressive system tract with large accommodation space and fast deeper lake water. Swiftly，the source area supply of Wensu Uplift decreases；the fan delta retrogrades towards the basin edge；the early developed sand is washed by the water and redeposited to be small sand bars. The delta in Yingmaili Uplift source area shrinks gradually and the near lakeshore sand bars apparently shrink.