A pilot test of the layer and well pattern interchange was carried out in Ng3-4 strata in the north of the west area of Gudao Oilfield. The layer and well pattern interchange altered the fluid flow direction and increased the swept volume.After the layer and well pattern interchange，the marked results of development and adjustment were achieved in the block，but the results varied greatly between individual wells. The Tanimoto coefficient was used to calculate the vector similarity between the fields of two discriminant parameters，i.e. the displacement pressure gradient and the water-oil seepage velocity ratio，and the water consumption control index was introduced to evaluate the response mechanism of the variable streamline. According to the response characteristics of oil wells，the responses were summarized into immediate response，delayed response，repeated response and no response. The research results of the response mechanism demonstrate that the streamline position of the existing strata where oil wells are located in and the differential distribution of oil and water in the well area directly affect the production status of remaining oil and the control degree of the high water consumption zones through the oil wells after the layer and well pattern interchange. As a result，the production of the oil wells is influenced after the layer and well pattern interchange.