Based on a large number of experimental data analysis and microscopic observation，the systemic evaluation of origin-rich lacustrine shale in the Paleogene Shahejie Formation in the central-north area of Huanghua depression was taken to determine the formation condition and resources potential of shale gas in the area through analyzing characteristics of the shale development，organic matter abundance and type，thermal evolution degree，reservoir performance and other aspects. The results show that the cumulative thickness of the effective shale is thick（>1 000 m）；the organic matter abundance is high（>1.0%）and the organic type is moderate（mainlyⅡ1 andⅡ2）；the degree of thermal evolution is mature to higher mature，and the reservoir properties are good；these conditions are favorable for shale gas formation. The parameters of thickness of shale with rich organic matter，organic carbon content，vitrinite reflectance，buried depth and formation pressure were taken as the evaluation standards for target optimization in the area through the comparison of the main features of the shale gas in America，Chinese continent and marine. The southwest of Qikou sag and the Zhangjuhe area were selected initially as favorable areas for shale gas exploration，especially Es3 the most favorable interval for shale gas formation.The total amount of prospective resource of shale oil and gas generated from the Shahejie Formation in the central-north area of Huanghua depression is 0.46×1012 m3，of which Es3 occupies 73%. It shows enormous potential of the shale gas reseurces there.